It'd only be dependant in-so-far as unported apps, and apps that have no Linux equivalant, go. Wine isn't sustainable as a "replacement" to Windows.. it's in a perpetual condition of playing catch-up with real Windows. And as such, it will only be needed as long as Windows is around, which will be as long as people use Windows, which will be as long as needed software is Windows-only.
I'd dread that the more dependent we become of this, the more Windows we are, in the sense that we keep running Windows apps to do personal computing. Thinking about a situation where everyone runs Wine for anything just makes me shiver.