You can usually get mplayer, flash, et al running on 64-bit Linux but it does require more work than a conventional 32-bit quick-and-easy installation. Aside from those initial install/setup routines, the rest of x86_64 Linux should be pretty much smooth sailing.
Quake Wars will not have a native 64-bit client, but using the 32-bit binary with the 32-bit userland will work, just like it works for Quake 4 and Doom 3.


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