There wasn't any Thunderbird 4.0 mail client release, but now that Firefox 5.0 is out there, Mozilla Messaging has announced the second and final beta release of Mozilla Thunderbird 5.0...
Nice feature of FF5 is that it allows aggressive optimization.
Did not notice much difference in test's however, when just compiled, i could feel difference in speed to older Firefox in such operations as loading pages(especially start up) and changing tabs. This is by no means personal experience, don't trust me for it.