In my case, Doom3 worked just fine on my Audigy 2ZS 5.1 setup using NumberOfSpeakers 6.
Originally Posted by johnc
However, As I recall Doom3 port had issues with sound and required a lot of mocking around with the supplied openal.so to get working sound, while Quake4 and ETQW more-or-less worked out of the box. (I bought all of them once the Linux port was out).
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