Originally Posted by Del_
The threading optimization is simply nvidia implimenting a hack that has been floating around for World of Warcraft in wine. You find the history of it here:
From that thread it is clear that this issue is special for WoW, but may also be of interest to Guild Wars 2. I can confirm that the patch does wonders for WoW on linux with wine, just as intended.
Thanks for the thourough testing, it confirms that this really is a special issue for WoW, while earlier indications were more anecdotal in nature.
What version of the game are you running? Are you running current or 2.4.3/3.3.5a/4.0.6a