It's basically nothing new to me. AMD drivers are very bad for wine. I only test some games like Rage and L4D2, Rage usually starts with some artefacts but not even after 1 min gameplay it crashes my HD 5670. L4D2 crashes even before. Most games like Nvidia cards with one exeption that is Killing Floor. As i already reported a bug to the KF devs and never got a response which is a bit annoying i still have to swap my gfx cards for the game i want to play. At least the gfx driver is automatically switched using gfxdetect