The Ongoing CPU Security Mitigation Impact On The Core i9 10900K Comet Lake
To little surprise at this stage, booting the system with the relevant mitigations disabled does offer measurable advantage for I/O heavy workloads like those applications making extensive use of the SQLite embedded database library.
LevelDB as Google's speedy key-value store used by Google Chrome and other software is also recording slight improvements from disabling the mitigations.
Or for software making heavy use of other Linux kernel interfaces like network-heavy tasks.